Diabetes mellitus is a chronic disease in which patients present with absolute or relative insulin deficiency. It effects about 6% of western populations and is a major contributing factor for heart attacks, strokes, kidney failure and peripheral vascular disease. Diabetes mellitus is also the leading cause of new blindness.

1. Types of Diabetes

There are four forms of the disease, classified as: types 1 and 2, gestational and other specific types.

a. Type 1 Diabetes

In people with type 1 diabetes the pancreas is not producing insulin, so blood glucose levels are higher than normal. People with this form of diabetes require daily insulin therapy to survive. This form is further split into idiopathic diabetes and immune mediated diabetes.

Type 1 accounts for around 10% to 15% of all people with diabetes. It is one of the most serious and common chronic diseases of childhood, with about half of the people with this form of diabetes developing the disease before age 18. It is also known as insulin dependent diabetes mellitus (IDDM) or juvenile-onset diabetes.

b. Type 2 Diabetes

Type 2 diabetes is marked by reduced levels of insulin (insulin deficiency) and/or the inability of the body to use insulin properly (insulin resistance). This form of the disease is most common among people aged 40 years and over and accounts for 85% to 90% of all people with diabetes. Most people with type 2 diabetes are obese.

c. Gestational Diabetes

Gestational diabetes occurs during pregnancy in about 3% to 8% of females not previously diagnosed with diabetes. It is a temporary form of diabetes and usually disappears after the baby is born. However, it is a marker of much greater risk of developing Type 2 diabetes later in life. Screening tests for gestational diabetes are usually performed around the 24th-28th week of pregnancy.

d. Other Specific Diabetes Types

This includes people who have diabetes as a result of a genetic defect, or exposure to certain drugs or chemicals.

2. Causes of Diabetes Mellitus

Diabetes is caused by resistance to, or deficient production of, the hormone insulin, which helps glucose move from the blood into the cells.

In type 1 immune mediated diabetes, pancreatic beta cell destruction results in failure to release insulin and ineffective transport of glucose. There is no known cause for idiopathic diabetes.

In type 2 diabetes, the beta cells release insulin but, receptors are insulin resistant and glucose transport is variable and inefficient. Some people may have conditions that can cause diabetes, such as Cushing’s syndrome, pancreatitis or liver disease.

Risk factors for type 2 diabetes include;

a. Obesity

b. History of Gestational diabetes

c. Lack of physical activity

d. Hypertension

e. Age 45+

f. Ethnic groupings other than anglo-saxon

g. Low HDL cholesterol levels

h. Impaired glucose tolerance

i. Family history

3. Signs and Symptoms of Diabetes

Symptoms of diabetes include; dehydration, unexplained weight loss, excessive thirst, frequent need to urinate, fatigue, lethargy, severe irritation and itching, excessive hunger, blurred vision, skin and urinary infections and vaginitis.

4. Diagnosis

Diabetes or impaired glucose tolerance may be detected on routine blood tests as part of a general health check up or investigation for other symptoms or diseases. Diabetes tests check blood glucose levels.

Fasting blood glucose levels are classified as:

Normal: less than 100 mg/dl

Prediabetes: 100 to 125 mg/dl

Diabetes: greater than 125mg/dl

Because symptoms can be mild, diabetes is often detected when a person suffers a problem that is caused by diabetes, such as a heart attack, stroke, neuropathy, poor wound healing or a foot ulcer, certain eye problems, certain fungal infections, or delivering a baby with macrosomia or hypoglycemia.

5. Diabetes Treatment

Effective treatment endeavors to normalize blood glucose and reduce complications using insulin replacement, diet and exercise. For those with very mild diabetes, diet plus weight loss plus exercise may be enough to keep blood glucose within reasonable levels.

Dietary changes should focus on the ideas of weight loss and blood sugar regulation by keeping the blood sugar levels relatively stable throughout the day, avoiding big peaks or troughs.

The principal treatment of type 1 diabetes, even from its earliest stages, is replacement of insulin combined with careful monitoring of blood glucose levels using blood testing monitors.

Type 2 diabetes may require oral anti-diabetic drugs to stimulate body insulin production and increase insulin sensitivity. Various forms of natural supplements for diabetes treatment have also been postulated as effective.

People with unstable diabetes, or those requiring many injections a day, may benefit from an insulin pump which is worn on the body and delivers a continuous infusion of insulin via a needle implanted into the body.

Gestational diabetes is fully treatable but requires careful medical supervision throughout the pregnancy. Even though it may be transient, untreated gestational diabetes can damage the health of the fetus or the mother.

Treatment for all forms of diabetes need not significantly impair normal activities, if sufficient patient training, awareness, appropriate care, discipline in testing and dosing of insulin is taken

6. Complications

Diabetes mellitus is the most common cause of adult kidney failure worldwide in the developed world. If undetected or poorly controlled, diabetes can lead to blindness, kidney failure, lower limb amputation, heart attack, stroke and impotence.

Diabetes is a hormone disorder that can cause problems with the kidneys, legs and feet, eyes, heart, nerves, and blood flow.Diabetes can cause many complications. Acute complications (hypoglycemia, ketoacidosis or nonketotic hyperosmolar coma) may occur if the disease is not adequately controlled. Diabetes is on the increase, probably because people are living longer, getting fatter and leading increasingly inactive lifestyles. Diabetes, without qualification, usually refers to diabetes mellitus, but there are several rarer conditions also named diabetes. The most common of these is diabetes insipidus in which the urine is not sweet; it can be caused by either kidney or pituitary gland damage. The term “type 1 diabetes” has universally replaced several former terms, including childhood-onset diabetes, juvenile diabetes, and insulin-dependent diabetes. “Type 2 diabetes” has also replaced several older terms, including adult-onset diabetes, obesity-related diabetes, and non-insulin-dependent diabetes. About 3 to 8 percent of pregnant women in the United States develop gestational diabetes.

Diabetes can also cause heart disease, stroke and even the need to remove a limb. Pregnant women can also get diabetes, called gestational diabetes. Type 1 diabetes mellitus—formerly known as insulin-dependent diabetes (IDDM), childhood diabetes. Type 2 diabetes mellitus—previously known as adult-onset diabetes, maturity-onset diabetes, or non-insulin-dependent diabetes mellitus (NIDDM). Symptoms of Type 2 diabetes may include fatigue, thirst, weight loss, blurred vision and frequent urination. Some people have no symptoms. A blood test can show if you have diabetes. Exercise, weight control and sticking to your meal plan can help control your diabetes. Most people affected by type 1 diabetes are otherwise healthy and of a healthy weight when onset occurs. Diet and exercise cannot reverse or prevent type 1 diabetes. Gestational diabetes is caused by the hormones of pregnancy or a shortage of insulin. Women with gestational diabetes may not experience any symptoms.

Diabetes mellitus is characterized by recurrent or persistent hyperglycemia. Diabetes affects more than 20 million Americans. About 54 million Americans have prediabetes. Medications have also been shown to provide similar benefit. Both diabetes drugs metformin and Precose have been shown to prevent the onset of type 2 diabetes in people with this pre-diabetes condition. A group of medicines known as ACE (angiotensin converting enzyme) inhibitors are sometimes used to reduce the risk of developing cardiovascular complications in diabetes and can also reduce the risk or progression of kidney and eye diseases. Microscopic or nanotechnological approaches are under investigation as well, in one proposed case with implanted stores of insulin metered out by a rapid response valve sensitive to blood glucose levels. Medications to treat diabetes include insulin and glucose-lowering pills called oral hypoglycemic drugs. Insulin preparations differ in how quickly they start to work and how long they remain active. Stop smoking, which hinders blood flow to the feet.

Diabetes Treatment and Prevention Tips

1. Diabetes is usually controlled by a healthy diet and regular exercise.

2. Magnesium may play a significant role in preventing Type 2 diabetes.

3. Use of metformin, rosiglitazone and valsartan.

4. Exercise, weight control and sticking to your meal plan can help control your diabetes.

5. Glucose in the blood is produced by the liver from the foods you eat.

6. Oral medications are still insufficient, insulin medications are considered.

7. Maintaining an ideal body weight and an active lifestyle may prevent the onset of type 2 diabetes.

8. Strict control of blood glucose, or blood sugar, as well as blood pressure